League Leaders - Offense
| Passing Yards | Complete List | |
Malachi Nelson
|
1. Malachi Nelson, NE | 3624 |
| 2. Eli Holstein, LAR | 3480 | |
| 3. Arch Manning, WAS | 3463 | |
| 4. Dante Moore, TB | 3166 | |
| 5. Drake Maye, ARI | 101 | |
| Rushing Yards | Complete List | |
K.C. Harrison
|
1. K.C. Harrison, BUF | 1040 |
| 2. Jeremiyah Love, WAS | 648 | |
| 3. Richard Young, MIA | 229 | |
| 4. Cole Cabana, NO | 194 | |
| 5. Rueben Owens, CAR | 164 | |
| Receiving Yards | Complete List | |
Johntay Cook
|
1. Johntay Cook, PIT | 950 |
| 2. John George, HOU | 661 | |
| 3. Jurrion Dickey, CIN | 656 | |
| 4. Aidan Mizell, DAL | 646 | |
| 5. Zachariah Branch, LAC | 627 | |
League Leaders - Defense
| Tackles | Complete List | |
Malik Muhammad
|
1. Malik Muhammad, SF | 46 |
| 2. Cormani McClain, MIN | 43 | |
| 3. Sheldon Albert, CIN | 39 | |
| 4. Makari Vickers, PHI | 38 | |
| 5. Malik Bryant, NO | 37 | |
| Sacks | Complete List | |
Peter Woods
|
1. Peter Woods, CLE | 6 |
| 2. Jaquavious Russaw, NYJ | 4 | |
| 3. Nicholas Daniels, HOU | 4 | |
| 4. Damion Johnston, TB | 3 | |
| 5. Javien Toviano, BUF | 2 | |
| Interceptions | Complete List | |
|
Malik Muhammad
|
1. Malik Muhammad, SF | 6 |
| 2. Javien Toviano, BUF | 3 | |
| 3. Dwight Amundson, MIA | 2 | |
| 4. A.J. Harris, SEA | 2 | |
| 5. Caleb Downs, CLE | 1 | |