League Leaders - Offense
| Passing Yards | Complete List | |
Kyler Murray
|
1. Kyler Murray, CHI | 4581 |
| 2. Josh Allen, BUF | 4518 | |
| 3. Cameron Ward, NO | 4494 | |
| 4. Tyler Van Dykc, HOU | 4393 | |
| 5. Malik Willis, SEA | 4226 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, LV | 1482 |
| 2. Chris Tyree, HOU | 1358 | |
| 3. Javonte Williams, ARI | 1304 | |
| 4. Aaron Jones, GB | 1184 | |
| 5. LJ Johnson, TB | 1162 | |
| Receiving Yards | Complete List | |
Justin Jefferson
|
1. Justin Jefferson, BUF | 2209 |
| 2. CeeDee Lamb, DAL | 1424 | |
| 3. Marquise Brown, CHI | 1423 | |
| 4. Tyler Boyd, TEN | 1330 | |
| 5. Chris Olave, NO | 1328 | |
League Leaders - Defense
| Tackles | Complete List | |
Brian Asamoah II
|
1. Brian Asamoah II, MIN | 70 |
| 2. Bobby Okereke, IND | 70 | |
| 3. Jerome Baker, MIA | 68 | |
| 4. Nick Bolton, KC | 67 | |
| 5. Devin Lloyd, JAX | 67 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, LAC | 19 |
| 2. Maxx Crosby, CHI | 18 | |
| 3. Nick Bosa, SF | 17 | |
| 4. T.J. Watt, PIT | 13 | |
| 5. DeMarcus Lawrence, IND | 12 | |
| Interceptions | Complete List | |
James Williams
|
1. James Williams, HOU | 10 |
| 2. Caleb Farley, DAL | 9 | |
| 3. Justin Simmons, DEN | 9 | |
| 4. Andrew Mukuba, LV | 8 | |
| 5. Tariq Woolen, SEA | 7 | |