League Leaders - Offense
| Passing Yards | Complete List | |
Bryce Young
|
1. Bryce Young, CAR | 5123 |
| 2. Joe Burrow, CIN | 5119 | |
| 3. Justin Herbert, LAC | 4843 | |
| 4. Jordan Love, GB | 4816 | |
| 5. Patrick Mahomes, KC | 4764 | |
| Rushing Yards | Complete List | |
Jahmyr Gibbs
|
1. Jahmyr Gibbs, DET | 1971 |
| 2. Joe Mixon, CIN | 1709 | |
| 3. Travis Etienne Jr, JAX | 1676 | |
| 4. Tony Pollard, DAL | 1598 | |
| 5. Isiah Pacheco, KC | 1513 | |
| Receiving Yards | Complete List | |
Ja'Marr Chase
|
1. Ja'Marr Chase, CIN | 2188 |
| 2. Jonathan Mingo, CAR | 1548 | |
| 3. Mike Evans, TB | 1501 | |
| 4. Jameson Williams, DET | 1483 | |
| 5. Garrett Wilson, NYJ | 1441 | |
League Leaders - Defense
| Tackles | Complete List | |
Kyzir White
|
1. Kyzir White, ARI | 102 |
| 2. Bobby Okereke, NYG | 101 | |
| 3. Blake Cashman, HOU | 101 | |
| 4. T.J. Edwards, CHI | 96 | |
| 5. Cole Holcomb, PIT | 94 | |
| Sacks | Complete List | |
Maxx Crosby
|
1. Maxx Crosby, LV | 17 |
| 2. Aaron Donald, LAR | 16 | |
| 3. Khalil Mack, LAC | 14 | |
| 4. Alim McNeill, DET | 12 | |
| 5. Nick Bosa, SF | 12 | |
| Interceptions | Complete List | |
Marshon Lattimore
|
1. Marshon Lattimore, DET | 11 |
| 2. Brandon Hill, JAX | 11 | |
| 3. DJ Turner II, CIN | 11 | |
| 4. Ifeatu Melifonwu, DET | 10 | |
| 5. Stephon Gilmore, DAL | 9 | |