League Leaders - Offense
| Passing Yards | Complete List | |
Chad Powers
|
1. Chad Powers, MIN | 6694 |
| 2. Josh Allen, JAX | 5791 | |
| 3. Dak Prescott, LAC | 5652 | |
| 4. Carl Middleton, IND | 5598 | |
| 5. Rakim Marrs, LAR | 5231 | |
| Rushing Yards | Complete List | |
Jonathan Taylor
|
1. Jonathan Taylor, MIA | 2175 |
| 2. Breece Hall, ARI | 2015 | |
| 3. Les Geaux, CLE | 1603 | |
| 4. Keanu Isles, NE | 1514 | |
| 5. Patrick Scott Jr, KC | 1456 | |
| Receiving Yards | Complete List | |
Trey Rogeezy
|
1. Trey Rogeezy, CIN | 2969 |
| 2. Aubrey Osborne, JAX | 2254 | |
| 3. Justin Jefferson, MIN | 2115 | |
| 4. Chris Charles, MIN | 2017 | |
| 5. Jameson Williams, NYG | 1954 | |
League Leaders - Defense
| Tackles | Complete List | |
Hamsah Nasirildeen
|
1. Hamsah Nasirildeen, NYJ | 61 |
| 2. Jeremy Chinn, NYJ | 51 | |
| 3. Devin Lloyd, NYJ | 49 | |
| 4. Divine Deablo, NYG | 46 | |
| 5. Davion Taylor, DAL | 46 | |
| Sacks | Complete List | |
Haason Reddick
|
1. Haason Reddick, JAX | 31 |
| 2. Chase Young, NE | 28 | |
| 3. Micah Parsons, IND | 25 | |
| 4. Ed Oliver, NE | 21 | |
| 5. Joey Bosa, TB | 18 | |
| Interceptions | Complete List | |
Denzel Ward
|
1. Denzel Ward, NE | 11 |
| 2. Xavien Howard, MIA | 10 | |
| 3. Eric Stokes, KC | 9 | |
| 4. Ifeatu Melifonwu, CAR | 9 | |
| 5. Eddie Jackson, DEN | 9 | |