League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, KC | 7061 |
| 2. Patrick Mahomes, MIA | 6667 | |
| 3. Mike Vick, NE | 6323 | |
| 4. Drew Brees, LAC | 5725 | |
| 5. Dak Prescott, SEA | 5335 | |
| Rushing Yards | Complete List | |
Walter Payton
|
1. Walter Payton, TEN | 1892 |
| 2. Nick Chubb, DEN | 1867 | |
| 3. Davii Snags, NYJ | 1547 | |
| 4. Joe Mixon, SEA | 1528 | |
| 5. Javonte Williams, DET | 1465 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, KC | 2903 |
| 2. Usain Bolt, MIA | 2518 | |
| 3. DeAndre Hopkins, LAC | 2049 | |
| 4. IShowSpeed W, NE | 1966 | |
| 5. Garrett Wilson, MIN | 1734 | |
League Leaders - Defense
| Tackles | Complete List | |
Derrick Thomas
|
1. Derrick Thomas, SF | 127 |
| 2. Tremaine Edmunds, CIN | 118 | |
| 3. Patrick Queen, TEN | 118 | |
| 4. Leighton Vander Esch, SF | 116 | |
| 5. terrell Suggs, JAX | 111 | |
| Sacks | Complete List | |
Joey Bosa
|
1. Joey Bosa, BUF | 27 |
| 2. T.J. Watt, NE | 24 | |
| 3. Jack Youngblood, MIA | 22 | |
| 4. Nick Bosa, KC | 21 | |
| 5. Brian Levin, SEA | 20 | |
| Interceptions | Complete List | |
Jaire Alexander
|
1. Jaire Alexander, KC | 13 |
| 2. Jalen Ramsey, KC | 12 | |
| 3. Budda Baker, MIA | 10 | |
| 4. Deion Sanders, MIA | 8 | |
| 5. Jeff Okudah, BUF | 7 | |