League Leaders - Offense
| Passing Yards | Complete List | |
Nate Gore
|
1. Nate Gore, WAS | 1000 |
| 2. Drake Maye, NO | 924 | |
| 3. Caleb Williams, JAX | 917 | |
| 4. Brock Purdy, HOU | 875 | |
| 5. Lamar Jackson, DAL | 860 | |
| Rushing Yards | Complete List | |
Jahmyr Gibbs
|
1. Jahmyr Gibbs, LAR | 408 |
| 2. Trey Benson, LV | 400 | |
| 3. Tyjae Spears, CIN | 385 | |
| 4. Johnathan Daniels, PIT | 380 | |
| 5. Jonathon Brooks, NYG | 380 | |
| Receiving Yards | Complete List | |
Deion Walden
|
1. Deion Walden, NO | 986 |
| 2. George DeVoe, ORL | 828 | |
| 3. Marvin Harrison Jr, WAS | 747 | |
| 4. Xavier Worthy, BAL | 719 | |
| 5. Josh Downs, LAC | 703 | |
League Leaders - Defense
| Tackles | Complete List | |
Michael Hunt
|
1. Michael Hunt, NE | 45 |
| 2. Jeff Bauer, ATL | 42 | |
| 3. DeMarvion Overshown, CIN | 41 | |
| 4. Denzel Spencer, DET | 38 | |
| 5. Philip Howard, CIN | 36 | |
| Sacks | Complete List | |
Chop Robinson
|
1. Chop Robinson, NO | 10 |
| 2. Nick Bosa, ARI | 8 | |
| 3. Myles Garrett, CLE | 7 | |
| 4. Maxx Crosby, KC | 7 | |
| 5. Sammy Keyes, DET | 6 | |
| Interceptions | Complete List | |
Ralph Green
|
1. Ralph Green, DAL | 4 |
| 2. Tykee Smith, IND | 4 | |
| 3. Elijah Jones, JAX | 3 | |
| 4. Jarius Fort, JAX | 3 | |
| 5. Denzel Ward, JAX | 3 | |