| Player Rushing Statistics | |||||||||
| Name | Att | Yds | Avg | Lng | Fmb | 20+ | Btk | TD | |
| 1. Jahmyr Gibbs, PAR | 20 | 93 | 4.7 | 15 | 0 | 0 | 4 | 1 | |
| 2. Derrick Woodson, TEN | 24 | 74 | 3.1 | 14 | 0 | 0 | 3 | 0 | |
| 3. De'Von Achane, NO | 13 | 51 | 3.9 | 11 | 0 | 0 | 4 | 1 | |
| 4. Jalen Fitzgerald, ORL | 8 | 44 | 5.5 | 22 | 0 | 1 | 2 | 2 | |
| 5. LaShawn Birmingham, ARI | 8 | 36 | 4.5 | 15 | 0 | 0 | 2 | 0 | |
| 6. Josh Duke, BAL | 11 | 29 | 2.6 | 8 | 0 | 0 | 2 | 0 | |
| 7. Tua Tagovailoa, DEN | 2 | 21 | 10.5 | 12 | 0 | 0 | 0 | 0 | |
| 8. Austin Oliver, NE | 7 | 17 | 2.4 | 9 | 0 | 0 | 3 | 0 | |
| 9. Spencer Miller, DEN | 3 | 3 | 1.0 | 3 | 0 | 0 | 0 | 0 | |
| 10. Donovan Hubbard, ARI | 1 | 1 | 1.0 | 1 | 0 | 0 | 1 | 0 | |
| 11. Nick Booth, TEN | 4 | 0 | 0.0 | 1 | 1 | 0 | 0 | 1 | |
| 12. Enrique Duncan, TEN | 1 | 0 | 0.0 | 0 | 0 | 0 | 0 | 0 | |
| 13. J.C. Addison, NO | 1 | -1 | -1.0 | 0 | 0 | 0 | 0 | 0 | |
| 14. Drake Maye, NO | 2 | -2 | -1.0 | 0 | 0 | 0 | 0 | 0 | |
| 15. John Thompson, PAR | 1 | -3 | -3.0 | 0 | 0 | 0 | 0 | 0 | |
| 16. Jordan Love, NYJ | 3 | -6 | -2.0 | 2 | 0 | 0 | 0 | 1 | |