League Leaders - Offense
| Passing Yards | Complete List | |
Kenny Pickett
|
1. Kenny Pickett, PIT | 3686 |
| 2. Desmond Ridder, ATL | 1958 | |
| 3. Skylar Thompson, MIA | 51 | |
| Rushing Yards | Complete List | |
Kenneth Walker III
|
1. Kenneth Walker III, SEA | 1201 |
| 2. Brian Robinson Jr, WAS | 1157 | |
| 3. Breece Hall, NYJ | 1069 | |
| 4. Dameon Pierce, HOU | 981 | |
| 5. Isiah Pacheco, KC | 862 | |
| Receiving Yards | Complete List | |
Jameson Williams
|
1. Jameson Williams, DET | 2536 |
| 2. Christian Watson, GB | 1368 | |
| 3. George Pickens, PIT | 1309 | |
| 4. Drake London, ATL | 1125 | |
| 5. Alec Pierce, IND | 1099 | |
League Leaders - Defense
| Tackles | Complete List | |
Derek Stingley Jr
|
1. Derek Stingley Jr, HOU | 77 |
| 2. Roger McCreary, TEN | 74 | |
| 3. Jaquan Brisker, CHI | 73 | |
| 4. Trent McDuffie, KC | 63 | |
| 5. Kyler Gordon, CHI | 63 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, DET | 22 |
| 2. Travon Walker, JAX | 12 | |
| 3. Arnold Ebiketie, ATL | 7 | |
| 4. Sam Williams, DAL | 6 | |
| 5. Kayvon Thibodeaux, NYG | 5 | |
| Interceptions | Complete List | |
Alontae Taylor
|
1. Alontae Taylor, NO | 7 |
| 2. DaRon Bland, DAL | 6 | |
| 3. Lewis Cine, MIN | 5 | |
| 4. Trent McDuffie, KC | 5 | |
| 5. Marcus Jones, NE | 5 | |