League Leaders - Offense
| Passing Yards | Complete List | |
Jared Goff
|
1. Jared Goff, DET | 7159 |
| 2. Jimmy Garoppolo, SF | 5636 | |
| 3. Aaron Rodgers, GB | 5410 | |
| 4. Joe Burrow, CIN | 5378 | |
| 5. Russell Wilson, DEN | 5078 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, TEN | 1973 |
| 2. Travis Etienne Jr, JAX | 1732 | |
| 3. Raheem Mostert, MIA | 1588 | |
| 4. Saquon Barkley, NYG | 1550 | |
| 5. Jonathan Taylor, IND | 1502 | |
| Receiving Yards | Complete List | |
Amon-Ra St. Brown
|
1. Amon-Ra St. Brown, DET | 2627 |
| 2. Jameson Williams, DET | 2536 | |
| 3. Tyreek Hill, MIA | 1932 | |
| 4. Deebo Samuel, SF | 1773 | |
| 5. Cooper Kupp, LAR | 1674 | |
League Leaders - Defense
| Tackles | Complete List | |
Bobby Wagner
|
1. Bobby Wagner, LAR | 114 |
| 2. Jayon Brown, LV | 111 | |
| 3. Josey Jewell, DEN | 104 | |
| 4. David Long Jr, TEN | 101 | |
| 5. Lavonte David, TB | 97 | |
| Sacks | Complete List | |
Myles Garrett
|
1. Myles Garrett, CLE | 22 |
| 2. Aidan Hutchinson, DET | 22 | |
| 3. Von Miller, BUF | 17 | |
| 4. Aaron Donald, LAR | 14 | |
| 5. Josh Allen, JAX | 14 | |
| Interceptions | Complete List | |
Xavien Howard
|
1. Xavien Howard, MIA | 9 |
| 2. Chidobe Awuzie, CIN | 8 | |
| 3. Lamarcus Joyner, NYJ | 7 | |
| 4. Alontae Taylor, NO | 7 | |
| 5. Jessie Bates III, CIN | 7 | |