League Leaders - Offense
| Passing Yards | Complete List | |
Tua Tagovailoa
|
1. Tua Tagovailoa, MIA | 5261 |
| 2. Mac Jones, NE | 4977 | |
| 3. Kyler Murray, ARI | 4783 | |
| 4. Anthony Richardson, TB | 4694 | |
| 5. Derek Carr, LV | 4678 | |
| Rushing Yards | Complete List | |
David Montgomery
|
1. David Montgomery, CHI | 1968 |
| 2. Jonathan Taylor, IND | 1534 | |
| 3. Miles Sanders, PHI | 1339 | |
| 4. Kareem Hunt, MIA | 1336 | |
| 5. Nick Chubb, CLE | 1291 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, MIA | 2918 |
| 2. Cooper Kupp, LAR | 2270 | |
| 3. DeAndre Hopkins, ARI | 1613 | |
| 4. Stefon Diggs, BUF | 1576 | |
| 5. Davante Adams, LV | 1431 | |
League Leaders - Defense
| Tackles | Complete List | |
Jeremiah Owusu-Koramoah
|
1. Jeremiah Owusu-Koramoah, CLE | 105 |
| 2. Jordyn Brooks, SEA | 103 | |
| 3. Fred Warner, SF | 102 | |
| 4. Jayon Brown, LV | 99 | |
| 5. Eric Kendricks, MIN | 99 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, NYG | 20 |
| 2. Aaron Donald, LAR | 20 | |
| 3. Chase Young, MIA | 19 | |
| 4. Von Miller, BUF | 19 | |
| 5. Montez Sweat, WAS | 19 | |
| Interceptions | Complete List | |
Tremaine Edmunds
|
1. Tremaine Edmunds, NYG | 8 |
| 2. Bobby Wagner, NYG | 8 | |
| 3. Tyson Campbell, JAX | 6 | |
| 4. Shaquill Griffin, JAX | 6 | |
| 5. L'Jarius Sneed, KC | 6 | |