League Leaders - Offense
| Passing Yards | Complete List | |
C.J. Stroud
|
1. C.J. Stroud, HOU | 4684 |
| 2. Caleb Williams, CHI | 4557 | |
| 3. Derek Carr, NO | 4513 | |
| 4. Brock Purdy, SF | 4483 | |
| 5. Jared Goff, DET | 4441 | |
| Rushing Yards | Complete List | |
Bijan Robinson
|
1. Bijan Robinson, ATL | 1243 |
| 2. Saquon Barkley, PHI | 1222 | |
| 3. Jerome Ford, CLE | 1202 | |
| 4. Josh Jacobs, GB | 1152 | |
| 5. Najee Harris, PIT | 1109 | |
| Receiving Yards | Complete List | |
D.K. Metcalf
|
1. D.K. Metcalf, SEA | 1541 |
| 2. Amon-Ra St. Brown, DET | 1541 | |
| 3. Jaylen Waddle, MIA | 1514 | |
| 4. Percy Harvin, SEA | 1342 | |
| 5. Rashee Rice, KC | 1329 | |
League Leaders - Defense
| Tackles | Complete List | |
Drew Sanders
|
1. Drew Sanders, DEN | 99 |
| 2. Omar Speights, LAR | 93 | |
| 3. Robert Spillane, NYJ | 92 | |
| 4. Jordyn Brooks, MIA | 90 | |
| 5. Trevin Wallace, CAR | 89 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 15 |
| 2. Jadeveon Clowney, CAR | 15 | |
| 3. Lukas Van Ness, GB | 13 | |
| 4. T.J. Watt, PIT | 12 | |
| 5. Nick Bosa, SF | 12 | |
| Interceptions | Complete List | |
C.J. Gardner-Johnson
|
1. C.J. Gardner-Johnson, PHI | 8 |
| 2. Kamari Lassiter, HOU | 8 | |
| 3. Jaire Alexander, GB | 8 | |
| 4. Julian Love, SEA | 8 | |
| 5. Denzel Ward, CLE | 7 | |