League Leaders - Offense
| Passing Yards | Complete List | |
Quinn Ewers
|
1. Quinn Ewers, PIT | 4932 |
| 2. Cam Ward, LV | 4919 | |
| 3. Kurtis Rourke, CLE | 4827 | |
| 4. Jaxson Dart, NO | 4296 | |
| 5. Shedeur Sanders, CAR | 4032 | |
| Rushing Yards | Complete List | |
Ashton Jeanty
|
1. Ashton Jeanty, NE | 1654 |
| 2. Omarion Hampton, LV | 1614 | |
| 3. Nicholas Singleton, GB | 1575 | |
| 4. Dylan Sampson, DAL | 1522 | |
| 5. Treveyon Henderson, HOU | 1384 | |
| Receiving Yards | Complete List | |
Tre Harris
|
1. Tre Harris, TEN | 1611 |
| 2. Evan Stewart, HOU | 1450 | |
| 3. Jae Jenkins, ARI | 1336 | |
| 4. Savion Williams, LV | 1326 | |
| 5. Tetairoa McMillan, WAS | 1168 | |
League Leaders - Defense
| Tackles | Complete List | |
Smael Mondon Jr.
|
1. Smael Mondon Jr., CLE | 71 |
| 2. Collin Oliver, CIN | 65 | |
| 3. Malachi Moore, IND | 58 | |
| 4. Keon Sabb, NYJ | 57 | |
| 5. Nick Emmanwori, KC | 56 | |
| Sacks | Complete List | |
|
Trey Moore
|
1. Trey Moore, TEN | 30 |
| 2. Deone Walker, NYG | 25 | |
| 3. Landon Jackson, TB | 23 | |
| 4. Princely Umanmielen, NYG | 21 | |
| 5. Abdul Carter, BAL | 19 | |
| Interceptions | Complete List | |
Nick Emmanwori
|
1. Nick Emmanwori, KC | 5 |
| 2. Cliff Peters, HOU | 5 | |
| 3. Jason Marshall Jr., KC | 5 | |
| 4. Kendal Daniels, LV | 4 | |
| 5. Aries Graham, MIA | 3 | |