League Leaders - Offense
| Passing Yards | Complete List | |
Brock Purdy
|
1. Brock Purdy, SF | 6249 |
| 2. Will Levis, TEN | 6137 | |
| 3. Patrick Mahomes, KC | 5647 | |
| 4. Trevor Lawrence, JAX | 5571 | |
| 5. J.J. McCarthy, MIN | 5227 | |
| Rushing Yards | Complete List | |
Trey Benson
|
1. Trey Benson, ARI | 1872 |
| 2. De'Von Achane, MIA | 1698 | |
| 3. James Cook, BUF | 1691 | |
| 4. Ashton Jeanty, NE | 1654 | |
| 5. Omarion Hampton, LV | 1614 | |
| Receiving Yards | Complete List | |
Justin Jefferson
|
1. Justin Jefferson, MIN | 2092 |
| 2. Brian Thomas Jr, JAX | 1864 | |
| 3. Rashee Rice, KC | 1756 | |
| 4. Deebo Samuel Sr, SF | 1724 | |
| 5. Tre Harris, TEN | 1611 | |
League Leaders - Defense
| Tackles | Complete List | |
Roquan Smith
|
1. Roquan Smith, BAL | 86 |
| 2. Matt Milano, BUF | 85 | |
| 3. Blake Cashman, MIN | 83 | |
| 4. Fred Warner, SF | 82 | |
| 5. Kyzir White, SEA | 80 | |
| Sacks | Complete List | |
|
Roquan Smith
|
1. Roquan Smith, BAL | 37 |
| 2. Byron Murphy II, SEA | 36 | |
| 3. Derick Hall, SEA | 32 | |
| 4. Trey Moore, TEN | 30 | |
| 5. Chase Young, NO | 30 | |
| Interceptions | Complete List | |
Sean Murphy-Bunting
|
1. Sean Murphy-Bunting, ARI | 8 |
| 2. Devon Witherspoon, SEA | 7 | |
| 3. Brandon Stephens, BAL | 6 | |
| 4. Jason Marshall Jr., KC | 5 | |
| 5. Nick Emmanwori, KC | 5 | |