League Leaders - Offense
| Passing Yards | Complete List | |
Tom Brady
|
1. Tom Brady, TB | 3391 |
| 2. Derek Carr, LV | 2647 | |
| 3. Desmond Ridder, ATL | 2531 | |
| 4. Kyler Murray, ARI | 2456 | |
| 5. Sam Howell, WAS | 2424 | |
| Rushing Yards | Complete List | |
Nick Chubb
|
1. Nick Chubb, CLE | 861 |
| 2. Alvin Kamara, NO | 855 | |
| 3. Austin Ekeler, LAC | 811 | |
| 4. Jonathan Taylor, IND | 793 | |
| 5. Najee Harris, PIT | 789 | |
| Receiving Yards | Complete List | |
Mike Evans
|
1. Mike Evans, TB | 940 |
| 2. Kyle Pitts, ATL | 918 | |
| 3. Odell Beckham Jr, TB | 908 | |
| 4. Stefon Diggs, BUF | 871 | |
| 5. Michael Thomas, NO | 827 | |
League Leaders - Defense
| Tackles | Complete List | |
Shaquille Leonard
|
1. Shaquille Leonard, IND | 57 |
| 2. Demario Davis, NO | 51 | |
| 3. Patrick Surtain II, DEN | 44 | |
| 4. Foyesade Oluokun, JAX | 43 | |
| 5. Dre Greenlaw, SF | 42 | |
| Sacks | Complete List | |
Chase Young
|
1. Chase Young, WAS | 22 |
| 2. Josh Sweat, PHI | 14 | |
| 3. Myles Garrett, CLE | 11 | |
| 4. Emmanuel Ogbah, MIA | 10 | |
| 5. Jaelan Phillips, MIA | 9 | |
| Interceptions | Complete List | |
Trevon Moehrig
|
1. Trevon Moehrig, LV | 12 |
| 2. Jordan Whitehead, NYJ | 8 | |
| 3. Lavonte David, TB | 8 | |
| 4. Malik Hooker, DAL | 8 | |
| 5. Rock Ya-Sin, LV | 8 | |