League Leaders - Offense
| Passing Yards | Complete List | |
Jake Jeffries
|
1. Jake Jeffries, ORL | 2343 |
| 2. Patrick Mahomes, KC | 2202 | |
| 3. Jordan Love, GB | 1970 | |
| 4. Joe Burrow, CIN | 1941 | |
| 5. Kyler Murray, LOU | 1889 | |
| Rushing Yards | Complete List | |
Taurean Ramsey
|
1. Taurean Ramsey, BKN | 862 |
| 2. Nick Chubb, MIN | 793 | |
| 3. Kenneth Walker III, SEA | 765 | |
| 4. Jameel Dukes, LAR | 735 | |
| 5. Dameon Pierce, TEN | 669 | |
| Receiving Yards | Complete List | |
Nico Collins
|
1. Nico Collins, HOU | 854 |
| 2. Ja'Marr Chase, CIN | 732 | |
| 3. Terry McLaurin, ORL | 703 | |
| 4. Bo Melton, KC | 681 | |
| 5. Jayden Reed, GB | 659 | |
League Leaders - Defense
| Tackles | Complete List | |
Channing Tindall
|
1. Channing Tindall, MIA | 39 |
| 2. DeMarvion Overshown, DAL | 39 | |
| 3. Fred Warner, SF | 36 | |
| 4. George Mayes, LV | 36 | |
| 5. Devin Lloyd, STL2 | 35 | |
| Sacks | Complete List | |
Myles Murphy
|
1. Myles Murphy, CIN | 11 |
| 2. Will Anderson Jr, HOU | 11 | |
| 3. Jeffery Simmons, TEN | 10 | |
| 4. James Smith-Williams, ORL | 9 | |
| 5. Jaren Moore, ORL | 9 | |
| Interceptions | Complete List | |
Jalen Ramsey
|
1. Jalen Ramsey, CHO | 7 |
| 2. Darrick Forrest, TEN | 6 | |
| 3. Trevon Brennan, CIN | 5 | |
| 4. Jartavius Martin, ORL | 5 | |
| 5. Nate Hobbs, BKN | 5 | |