League Leaders - Offense
| Passing Yards | Complete List | |
Will Levis
|
1. Will Levis, TB | 2947 |
| 2. Bryce Young, HOU | 2264 | |
| 3. Tanner McKee, KC | 782 | |
| 4. Jaren Hall, CLE | 97 | |
| 5. Clayton Tune, LV | 16 | |
| Rushing Yards | Complete List | |
Bijan Robinson
|
1. Bijan Robinson, MIA | 528 |
| 2. Deuce Vaughn, NYG | 300 | |
| 3. Devon Achane, IND | 281 | |
| 4. Roschon Johnson, CAR | 224 | |
| 5. Tank Bigsby, DAL | 152 | |
| Receiving Yards | Complete List | |
Zay Flowers
|
1. Zay Flowers, CLE | 590 |
| 2. Jaxon Smith-Njigba, CAR | 551 | |
| 3. Michael Mayer, DAL | 546 | |
| 4. Dalton Kincaid, DET | 522 | |
| 5. Luke Musgrave, MIA | 511 | |
League Leaders - Defense
| Tackles | Complete List | |
Devon Witherspon
|
1. Devon Witherspon, DET | 39 |
| 2. Cam Smith, TB | 38 | |
| 3. Antonio Johnson, PHI | 38 | |
| 4. Will Anderson Jr, ARI | 38 | |
| 5. Joey Porter Jr, BAL | 37 | |
| Sacks | Complete List | |
Lukas Van Ness
|
1. Lukas Van Ness, PHI | 7 |
| 2. Trenton Simpson, KC | 7 | |
| 3. Tyree Wilson, LV | 5 | |
| 4. Keion White, HOU | 5 | |
| 5. Nolan Smith, SEA | 5 | |
| Interceptions | Complete List | |
Antonio Johnson
|
1. Antonio Johnson, PHI | 3 |
| 2. Cam Smith, TB | 3 | |
| 3. B Ojulari, NO | 2 | |
| 4. Brian Branch, LAC | 1 | |
| 5. DJ Turner, LAC | 1 | |