League Leaders - Offense
| Passing Yards | Complete List | |
Desmond Ridder
|
1. Desmond Ridder, ATL | 2255 |
| 2. Sam Howell, IND | 1982 | |
| 3. Matt Corral, DET | 1909 | |
| 4. Malik Willis, TEN | 1907 | |
| 5. Kenny Pickett, PIT | 1191 | |
| Rushing Yards | Complete List | |
Breece Hall
|
1. Breece Hall, NYJ | 641 |
| 2. James Cook, BUF | 635 | |
| 3. Zamir White, PHI | 566 | |
| 4. Pierre Strong Jr, NE | 455 | |
| 5. Kenneth Walker III, SF | 252 | |
| Receiving Yards | Complete List | |
Chris Olave
|
1. Chris Olave, NO | 864 |
| 2. Drake London, ATL | 840 | |
| 3. Bo Melton, LAC | 797 | |
| 4. Jameson Williams, DET | 756 | |
| 5. James Mitchell, LAC | 474 | |
League Leaders - Defense
| Tackles | Complete List | |
Dane Belton
|
1. Dane Belton, NYG | 22 |
| 2. Troy Andersen, ATL | 20 | |
| 3. Daxton Hill, CIN | 19 | |
| 4. Devin Lloyd, CIN | 18 | |
| 5. Kalon Barnes, CAR | 18 | |
| Sacks | Complete List | |
Terrel Bernard
|
1. Terrel Bernard, BUF | 8 |
| 2. Amare Barno, DET | 5 | |
| 3. Kyron Johnson, PHI | 5 | |
| 4. Sterling Weatherford, IND | 4 | |
| 5. Jordan Davis, PHI | 2 | |
| Interceptions | Complete List | |
JT Woods
|
1. JT Woods, LAC | 11 |
| 2. Alontae Taylor, NO | 8 | |
| 3. Cam Taylor-Britt, CIN | 7 | |
| 4. Nick Cross, IND | 7 | |
| 5. Lewis Cine, MIN | 6 | |