League Leaders - Offense
| Passing Yards | Complete List | |
Jameis Winston
|
1. Jameis Winston, NO | 2680 |
| 2. Desmond Ridder, ATL | 2255 | |
| 3. Justin Herbert, LAC | 2215 | |
| 4. Tom Brady, TB | 2181 | |
| 5. Baker Mayfield, CAR | 2136 | |
| Rushing Yards | Complete List | |
Joe Mixon
|
1. Joe Mixon, CIN | 734 |
| 2. Javonte Williams, DEN | 715 | |
| 3. Breece Hall, NYJ | 641 | |
| 4. James Cook, BUF | 635 | |
| 5. Cam Akers, LAR | 581 | |
| Receiving Yards | Complete List | |
Tyreek Hill
|
1. Tyreek Hill, MIA | 1076 |
| 2. Chris Olave, NO | 864 | |
| 3. Drake London, ATL | 840 | |
| 4. Terry McLaurin, WAS | 807 | |
| 5. Bo Melton, LAC | 797 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin White
|
1. Devin White, TB | 32 |
| 2. Jeremiah Owusu-Koramoah, CLE | 31 | |
| 3. Logan Wilson, CIN | 30 | |
| 4. Demario Davis, NO | 29 | |
| 5. Tyrann Mathieu, NO | 26 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, SF | 14 |
| 2. Myles Garrett, CLE | 11 | |
| 3. Chase Young, WAS | 10 | |
| 4. Chandler Jones, LV | 9 | |
| 5. Noah Dawkins, BUF | 9 | |
| Interceptions | Complete List | |
JT Woods
|
1. JT Woods, LAC | 11 |
| 2. Harrison Smith, MIN | 11 | |
| 3. Budda Baker, ARI | 9 | |
| 4. Adrian Amos, MIN | 9 | |
| 5. James Bradberry IV, PHI | 8 | |