League Leaders - Offense
| Passing Yards | Complete List | |
| Rushing Yards | Complete List | |
Ben Whitfield
|
1. Ben Whitfield, ARI | 215 |
| 2. Marquis Thurston, PIT | 147 | |
| 3. Zaire Sheard, JAX | 143 | |
| 4. Deontay Casey, LV | 116 | |
| 5. Calvin Jackson, NO | 98 | |
| Receiving Yards | Complete List | |
Juwan Philbin
|
1. Juwan Philbin, TEN | 734 |
| 2. Rashaun McFadden, LAC | 536 | |
| 3. Chad Clancy, GB | 511 | |
| 4. Jeremy Campbell, KC | 382 | |
| 5. Tavaris Carr, NO | 244 | |
League Leaders - Defense
| Tackles | Complete List | |
Bryan Rivers
|
1. Bryan Rivers, CHI | 59 |
| 2. Seth Washington, CIN | 47 | |
| 3. Nathan Winters, IND | 41 | |
| 4. Doug Huffman, PIT | 39 | |
| 5. Jerome Hood, MIN | 37 | |
| Sacks | Complete List | |
Marcus Nowell
|
1. Marcus Nowell, NYG | 4 |
| 2. Keegan Gamble, DET | 3 | |
| 3. Taylor Woodbury, HOU | 3 | |
| 4. Mason Rowe, HOU | 2 | |
| 5. Kevin Webber, NE | 2 | |
| Interceptions | Complete List | |
|
Bryan Rivers
|
1. Bryan Rivers, CHI | 1 |
| 2. Mike Stevens, NO | 1 | |
| 3. Alex Freeman, ARI | 1 | |
| 4. Doug Huffman, PIT | 1 | |
| 5. Barry Davis, CLE | 1 | |