League Leaders - Offense
| Passing Yards | Complete List | |
Desmond Ridder
|
1. Desmond Ridder, BUF | 4337 |
| 2. Greg Jones, ATL | 4170 | |
| 3. Michael Penix Jr, CAR | 4092 | |
| 4. Caleb Williams, CHI | 4092 | |
| 5. Joe Burrow, CIN | 3994 | |
| Rushing Yards | Complete List | |
Bijan Robinson
|
1. Bijan Robinson, ATL | 1100 |
| 2. De'Von Achane, MIA | 1046 | |
| 3. Breece Hall, NYJ | 1008 | |
| 4. Bucky Irving, NE | 972 | |
| 5. Isiah Pacheco, KC | 925 | |
| Receiving Yards | Complete List | |
J.J. Reese
|
1. J.J. Reese, CAR | 1537 |
| 2. Josh Downs, IND | 1201 | |
| 3. Keon Coleman, BUF | 1195 | |
| 4. Justin Jefferson, MIN | 1135 | |
| 5. Bruce McIntosh, CIN | 1110 | |
League Leaders - Defense
| Tackles | Complete List | |
Aqeel Alston
|
1. Aqeel Alston, CLE | 94 |
| 2. Matthew Cooper, TEN | 91 | |
| 3. Matt Green, IND | 90 | |
| 4. Edgerrin Cooper, GB | 88 | |
| 5. Ernest Jones, LAR | 84 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, DET | 18 |
| 2. Maxx Crosby, LV | 16 | |
| 3. Kayvon Thibodeaux, NYG | 14 | |
| 4. Stefan Jacobs, PIT | 13 | |
| 5. Ruke Orhorhoro, ATL | 13 | |
| Interceptions | Complete List | |
Drew Sanders
|
1. Drew Sanders, MIA | 6 |
| 2. Tre Jackson, DEN | 6 | |
| 3. Patrick Queen, PIT | 6 | |
| 4. Trent McDuffie, NYJ | 5 | |
| 5. Leroy Maynard, TB | 4 | |