League Leaders - Offense
| Passing Yards | Complete List | |
Matthew Stafford
|
1. Matthew Stafford, LAR | 1239 |
| 2. Josh Allen, BUF | 1216 | |
| 3. C.J. Stroud, HOU | 1206 | |
| 4. Jared Goff, DET | 1135 | |
| 5. Baker Mayfield, TB | 1068 | |
| Rushing Yards | Complete List | |
Kenneth Walker III
|
1. Kenneth Walker III, SEA | 681 |
| 2. Chuba Hubbard, CAR | 617 | |
| 3. Saquon Barkley, PHI | 467 | |
| 4. Josh Jacobs, GB | 462 | |
| 5. D'Andre Swift, CHI | 446 | |
| Receiving Yards | Complete List | |
Cooper Kupp
|
1. Cooper Kupp, LAR | 450 |
| 2. Curtis Samuel, BUF | 449 | |
| 3. D.J. Chark Jr, NO | 429 | |
| 4. CeeDee Lamb, DAL | 401 | |
| 5. Amon-Ra St. Brown, DET | 392 | |
League Leaders - Defense
| Tackles | Complete List | |
Akeem Davis-Gaither
|
1. Akeem Davis-Gaither, CIN | 27 |
| 2. Tony Adams, NYJ | 22 | |
| 3. Demario Davis, NO | 21 | |
| 4. Daiyan Henley, LAC | 21 | |
| 5. Jordan Poyer, MIA | 20 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 5 |
| 2. Osa Odighizuwa, DAL | 4 | |
| 3. Vita Vea, TB | 4 | |
| 4. Dante Stills, ARI | 4 | |
| 5. Shaquil Barrett, MIA | 4 | |
| Interceptions | Complete List | |
Jessie Bates III
|
1. Jessie Bates III, ATL | 5 |
| 2. Joshua Williams, KC | 4 | |
| 3. James Williams, TEN | 4 | |
| 4. L'Jarius Sneed, TEN | 4 | |
| 5. Xavier McKinney, GB | 4 | |