League Leaders - Offense
| Passing Yards | Complete List | |
Jared Goff
|
1. Jared Goff, DET | 994 |
| 2. Jalen Hurts, PHI | 814 | |
| 3. Russell Wilson, DEN | 795 | |
| 4. Tom Brady, TB | 763 | |
| 5. Kyler Murray, ARI | 759 | |
| Rushing Yards | Complete List | |
Saquon Barkley
|
1. Saquon Barkley, NYG | 488 |
| 2. Austin Ekeler, LAC | 385 | |
| 3. Ronald Jones II, KC | 371 | |
| 4. Leonard Fournette, TB | 329 | |
| 5. Breece Hall, NYJ | 327 | |
| Receiving Yards | Complete List | |
D.J. Chark Jr
|
1. D.J. Chark Jr, DET | 335 |
| 2. Jameson Williams, DET | 304 | |
| 3. Curtis Samuel, WAS | 279 | |
| 4. Davante Adams, LV | 270 | |
| 5. A.J. Brown, PHI | 252 | |
League Leaders - Defense
| Tackles | Complete List | |
Jamal Adams
|
1. Jamal Adams, SEA | 21 |
| 2. Kamu Grugier-Hill, HOU | 18 | |
| 3. Eric Kendricks, MIN | 18 | |
| 4. Josey Jewell, DEN | 17 | |
| 5. Sidney Jones IV, SEA | 17 | |
| Sacks | Complete List | |
Haason Reddick
|
1. Haason Reddick, PHI | 5 |
| 2. Arik Armstead, SF | 4 | |
| 3. Von Miller, BUF | 4 | |
| 4. Emmanuel Ogbah, MIA | 4 | |
| 5. Chase Young, WAS | 4 | |
| Interceptions | Complete List | |
Juan Thornhill
|
1. Juan Thornhill, KC | 5 |
| 2. Chris Harris Jr, NE | 4 | |
| 3. Chidobe Awuzie, CIN | 3 | |
| 4. John Johnson III, CLE | 3 | |
| 5. Vonn Bell, CIN | 3 | |