League Leaders - Offense
| Passing Yards | Complete List | |
Lamar Jackson
|
1. Lamar Jackson, BAL | 2554 |
| 2. Trey Lance, SF | 1966 | |
| 3. Peyton Manning, IND | 1402 | |
| 4. Malik Willis, PHI | 1363 | |
| 5. Justin Herbert, TEN | 1156 | |
| Rushing Yards | Complete List | |
Tony Pollard
|
1. Tony Pollard, DAL | 564 |
| 2. J.K. Dobbins, BAL | 441 | |
| 3. Christian McCaffrey, SF | 414 | |
| 4. Lamar Jackson, BAL | 229 | |
| 5. Travis Etienne Jr, JAX | 224 | |
| Receiving Yards | Complete List | |
Kadarius Toney
|
1. Kadarius Toney, BAL | 959 |
| 2. Andrew Newsome, BAL | 777 | |
| 3. Danny Gray, SF | 627 | |
| 4. Curtis Samuel, SF | 600 | |
| 5. Deebo Samuel, SF | 575 | |
League Leaders - Defense
| Tackles | Complete List | |
Fred Warner
|
1. Fred Warner, SF | 25 |
| 2. Patrick Queen, BAL | 22 | |
| 3. Emmanuel Moseley, SF | 17 | |
| 4. Ambry Thomas, SF | 16 | |
| 5. Odafe Oweh, BAL | 16 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, SF | 12 |
| 2. Odafe Oweh, BAL | 12 | |
| 3. Calais Campbell, BAL | 7 | |
| 4. Rashan Gary, PHI | 7 | |
| 5. Kayvon Thibodeaux, NYG | 6 | |
| Interceptions | Complete List | |
Kevin Byard
|
1. Kevin Byard, BAL | 6 |
| 2. Jalyn Armour-Davis, BAL | 3 | |
| 3. Kyle Hamilton, BAL | 3 | |
| 4. Trevon Diggs, DAL | 3 | |
| 5. Micah Hyde, PHI | 3 | |