League Leaders - Offense
| Passing Yards | Complete List | |
Davis Mills
|
1. Davis Mills, HOU | 3499 |
| 2. Tom Brady, PHI | 3210 | |
| 3. Derek Carr, LV | 2799 | |
| 4. Mac Jones, NE | 2567 | |
| 5. Joe Burrow, CIN | 2549 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, TEN | 1139 |
| 2. Damien Harris, NE | 1104 | |
| 3. Dalvin Cook, MIN | 955 | |
| 4. Herschel Walker, DAL | 917 | |
| 5. Joe Mixon, CIN | 910 | |
| Receiving Yards | Complete List | |
Bryan Garner
|
1. Bryan Garner, HOU | 1134 |
| 2. Darius Slayton, HOU | 930 | |
| 3. Christian Kirk, JAX | 900 | |
| 4. DeVonta Smith, PHI | 882 | |
| 5. Davante Adams, LV | 870 | |
League Leaders - Defense
| Tackles | Complete List | |
Jordyn Brooks
|
1. Jordyn Brooks, SEA | 61 |
| 2. Isaiah Simmons, ARI | 56 | |
| 3. Bobby Wagner, LAR | 53 | |
| 4. Johnathan Abram, LV | 50 | |
| 5. Foyesade Oluokun, JAX | 50 | |
| Sacks | Complete List | |
Odafe Oweh
|
1. Odafe Oweh, BAL | 14 |
| 2. Josh Allen, JAX | 9 | |
| 3. Myles Garrett, CLE | 9 | |
| 4. Von Miller, BUF | 8 | |
| 5. Micah Parsons, DAL | 8 | |
| Interceptions | Complete List | |
Dane Cruikshank
|
1. Dane Cruikshank, NO | 7 |
| 2. Mike Hughes, DET | 6 | |
| 3. Derwin James Jr, LAC | 6 | |
| 4. Jeremy Chinn, CAR | 6 | |
| 5. Jaquan Brisker, CHI | 5 | |