League Leaders - Offense
| Passing Yards | Complete List | |
C.J. Stroud
|
1. C.J. Stroud, HOU | 4999 |
| 2. Jalen Hurts, PHI | 4449 | |
| 3. Jared Goff, DET | 4072 | |
| 4. Bryce Young, CAR | 3924 | |
| 5. Josh Allen, BUF | 3920 | |
| Rushing Yards | Complete List | |
Christian McCaffrey
|
1. Christian McCaffrey, SF | 1325 |
| 2. Kenneth Walker III, SEA | 1288 | |
| 3. Aaron Jones, MIN | 1282 | |
| 4. Jonathan Taylor, IND | 1278 | |
| 5. Najee Harris, PIT | 1141 | |
| Receiving Yards | Complete List | |
Cooper Kupp
|
1. Cooper Kupp, LAR | 1264 |
| 2. Mike Evans, TB | 1258 | |
| 3. Justin Jefferson, MIN | 1237 | |
| 4. George Pickens, PIT | 1225 | |
| 5. Jayden Reed, GB | 1219 | |
League Leaders - Defense
| Tackles | Complete List | |
Demario Davis
|
1. Demario Davis, NO | 83 |
| 2. Ja'Whaun Bentley, NE | 83 | |
| 3. Foyesade Oluokun, JAX | 82 | |
| 4. Jeremiah Owusu-Koramoah, CLE | 80 | |
| 5. Divine Deablo, LV | 78 | |
| Sacks | Complete List | |
Danielle Hunter
|
1. Danielle Hunter, HOU | 16 |
| 2. Aidan Hutchinson, DET | 16 | |
| 3. Myles Garrett, CLE | 15 | |
| 4. T.J. Watt, PIT | 14 | |
| 5. Nick Bosa, SF | 14 | |
| Interceptions | Complete List | |
Lewis Cine
|
1. Lewis Cine, PHI | 8 |
| 2. Kyzir White, TB | 8 | |
| 3. Derek Stingley Jr, HOU | 8 | |
| 4. Brandon Jones, DEN | 7 | |
| 5. Eric Murray, HOU | 7 | |