League Leaders - Offense
| Passing Yards | Complete List | |
Daunte Culpepper
|
1. Daunte Culpepper, MIN | 5173 |
| 2. Brett Favre, GB | 4754 | |
| 3. Tom Brady, NE | 4659 | |
| 4. Peyton Manning, DEN | 4227 | |
| 5. Michael Vick, ATL | 4190 | |
| Rushing Yards | Complete List | |
Jim Brown
|
1. Jim Brown, CLE | 1981 |
| 2. Walter Payton, CHI | 1527 | |
| 3. Barry Sanders, DET | 1284 | |
| 4. O.J. Simpson, BUF | 1174 | |
| 5. Keaton Mitchell, BAL | 898 | |
| Receiving Yards | Complete List | |
Zay Flowers
|
1. Zay Flowers, BAL | 1330 |
| 2. Michael Irvin, DAL | 1310 | |
| 3. Harold Carmichael, PHI | 1168 | |
| 4. Walter Payton, CHI | 1087 | |
| 5. Luke Musgrave, GB | 1070 | |
League Leaders - Defense
| Tackles | Complete List | |
Marte Mapu
|
1. Marte Mapu, NE | 79 |
| 2. Deonte Banks, NYG | 61 | |
| 3. Emmanuel Forbes Jr, WAS | 60 | |
| 4. Richard Sherman, SEA | 56 | |
| 5. Tyrique Stevenson, CHI | 56 | |
| Sacks | Complete List | |
Jason Taylor
|
1. Jason Taylor, MIA | 15 |
| 2. Terrell Suggs, BAL | 11 | |
| 3. Derrick Thomas, KC | 8 | |
| 4. Tyree Wilson, LV | 7 | |
| 5. Gervon Dexter, CHI | 6 | |
| Interceptions | Complete List | |
Antonio Cromartie
|
1. Antonio Cromartie, LAC | 12 |
| 2. Sean Taylor, WAS | 10 | |
| 3. Kelee Ringo, PHI | 8 | |
| 4. Christian Gonzalez, NE | 7 | |
| 5. Richard Sherman, SEA | 7 | |