League Leaders - Offense
| Passing Yards | Complete List | |
Joe Burrow
|
1. Joe Burrow, CIN | 5254 |
| 2. Daunte Culpepper, MIN | 5173 | |
| 3. Dak Prescott, DAL | 5137 | |
| 4. Brett Favre, GB | 4754 | |
| 5. Tom Brady, NE | 4659 | |
| Rushing Yards | Complete List | |
Christian McCaffrey
|
1. Christian McCaffrey, SF | 2044 |
| 2. Jim Brown, CLE | 1981 | |
| 3. Tony Pollard, DAL | 1792 | |
| 4. D'Andre Swift, PHI | 1607 | |
| 5. Walter Payton, CHI | 1527 | |
| Receiving Yards | Complete List | |
Justin Jefferson
|
1. Justin Jefferson, MIN | 2132 |
| 2. Calvin Austin, PIT | 1520 | |
| 3. Ja'Marr Chase, CIN | 1488 | |
| 4. Tyquan Thornton, NE | 1472 | |
| 5. Cooper Kupp, LAR | 1347 | |
League Leaders - Defense
| Tackles | Complete List | |
Nick Bolton
|
1. Nick Bolton, KC | 105 |
| 2. Bobby Okereke, NYG | 97 | |
| 3. Divine Deablo, LV | 94 | |
| 4. C.J. Mosley, NYJ | 92 | |
| 5. Shaq Thompson, CAR | 88 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 16 |
| 2. Haason Reddick, PHI | 15 | |
| 3. Myles Garrett, CLE | 15 | |
| 4. Jason Taylor, MIA | 15 | |
| 5. Montez Sweat, CHI | 11 | |
| Interceptions | Complete List | |
Antonio Cromartie
|
1. Antonio Cromartie, LAC | 12 |
| 2. Jessie Bates III, ATL | 11 | |
| 3. Kevin Byard III, PHI | 11 | |
| 4. Sean Taylor, WAS | 10 | |
| 5. Darius Slay Jr, PHI | 10 | |