League Leaders - Offense
| Passing Yards | Complete List | |
Damon Boone
|
1. Damon Boone, DET | 5809 |
| 2. Troy Robertson, NO | 4595 | |
| 3. Shawn York, CIN | 4331 | |
| 4. Shedeur Sanders, TKY | 4296 | |
| 5. Jordan Baker, PAR | 4221 | |
| Rushing Yards | Complete List | |
Kenneth Walker III
|
1. Kenneth Walker III, SEA | 1450 |
| 2. Rachaad White, TB | 1391 | |
| 3. Bijan Robinson, ATL | 1228 | |
| 4. Jonathan Taylor, IND | 1157 | |
| 5. Trey Benson, ARI | 1082 | |
| Receiving Yards | Complete List | |
Jameson Williams
|
1. Jameson Williams, DET | 2023 |
| 2. Jeff Robbins, NO | 1410 | |
| 3. Sam LaPorta, DET | 1342 | |
| 4. Khalil Shakir, LV | 1301 | |
| 5. Silas Foster, NO | 1287 | |
League Leaders - Defense
| Tackles | Complete List | |
Drew Sanders
|
1. Drew Sanders, DEN | 107 |
| 2. Daiyan Henley, ATL | 94 | |
| 3. Nick Bolton, KC | 94 | |
| 4. Patrick Queen, PIT | 91 | |
| 5. Payton Wilson, HST | 90 | |
| Sacks | Complete List | |
Aidan Hutchinson
|
1. Aidan Hutchinson, DET | 18 |
| 2. Alex Highsmith, BAL | 16 | |
| 3. Devin Ramsay, WAS | 15 | |
| 4. Nick Bosa, SF | 13 | |
| 5. Matt Meredith, DET | 13 | |
| Interceptions | Complete List | |
Randy Reese
|
1. Randy Reese, TB | 8 |
| 2. Kyle Kitchens, ARI | 7 | |
| 3. Max Melton, ARI | 7 | |
| 4. Romeo Forbes, CLE | 6 | |
| 5. Tyree Grimes, SDG | 6 | |