League Leaders - Offense
| Passing Yards | Complete List | |
Allen Iverson
|
1. Allen Iverson, CIN | 4115 |
| 2. Hunter Brown, SEA | 3507 | |
| 3. Mark Sieczkowski, DET | 2817 | |
| 4. Tevin Berry, CHI | 1084 | |
| 5. Mark Rivers, LAR | 753 | |
| Rushing Yards | Complete List | |
Dillon Coakley
|
1. Dillon Coakley, CIN | 812 |
| 2. DeMarco Spencer, TB | 444 | |
| 3. Chuck Edwards, NO | 330 | |
| 4. Donovan Hunt, BUF | 282 | |
| 5. Brian Portis, PIT | 195 | |
| Receiving Yards | Complete List | |
Alex Rudd
|
1. Alex Rudd, KC | 882 |
| 2. Damien Peppers, GB | 852 | |
| 3. Phillip Knox, BAL | 791 | |
| 4. Marquise Flowers, ATL | 723 | |
| 5. Micah Southward, MIN | 579 | |
League Leaders - Defense
| Tackles | Complete List | |
Sean Taylor
|
1. Sean Taylor, TEN | 51 |
| 2. Channing Woodward, PIT | 48 | |
| 3. J.D. McCray, DAL | 45 | |
| 4. Cameron Allison, TEN | 44 | |
| 5. Jahlil Keyes, CHI | 42 | |
| Sacks | Complete List | |
Josh Pemberton
|
1. Josh Pemberton, ARI | 13 |
| 2. John Preston, MIA | 10 | |
| 3. Marvin Charleston, NO | 8 | |
| 4. Alex Hooker, HOU | 7 | |
| 5. Roy Vaughn, NE | 5 | |
| Interceptions | Complete List | |
J.D. McCray
|
1. J.D. McCray, DAL | 5 |
| 2. Derek Capers, MIA | 5 | |
| 3. Glen Watkins, HOU | 5 | |
| 4. Rick Wilkinson, SF | 4 | |
| 5. Tyler Ware, ATL | 4 | |