League Leaders - Offense
| Passing Yards | Complete List | |
Trey Lance
|
1. Trey Lance, SF | 4496 |
| 2. Allen Iverson, CIN | 4115 | |
| 3. Baker Mayfield, PHI | 4105 | |
| 4. Patrick Mahomes, KC | 4026 | |
| 5. Kyler Murray, ARI | 3757 | |
| Rushing Yards | Complete List | |
Tony Pollard
|
1. Tony Pollard, KC | 1481 |
| 2. Derrick Henry, LV | 1366 | |
| 3. Cam Akers, LAR | 1352 | |
| 4. D'Andre Swift, DET | 1237 | |
| 5. Jonathan Taylor, IND | 1221 | |
| Receiving Yards | Complete List | |
George Pickens
|
1. George Pickens, SF | 1739 |
| 2. Jaylen Waddle, CIN | 1470 | |
| 3. Ja'Marr Chase, MIA | 1210 | |
| 4. Courtland Sutton, NYG | 1185 | |
| 5. Albert Okwuegbunam, IND | 1170 | |
League Leaders - Defense
| Tackles | Complete List | |
Myles Jack
|
1. Myles Jack, PIT | 78 |
| 2. Matt Milano, BUF | 69 | |
| 3. Troy Andersen, ATL | 66 | |
| 4. Shaq Thompson, CAR | 65 | |
| 5. Roquan Smith, CHI | 60 | |
| Sacks | Complete List | |
Von Miller
|
1. Von Miller, BUF | 21 |
| 2. Emmanuel Ogbah, MIA | 13 | |
| 3. Josh Pemberton, ARI | 13 | |
| 4. Nick Bosa, SF | 13 | |
| 5. Micah Parsons, DAL | 12 | |
| Interceptions | Complete List | |
Amani Oruwariye
|
1. Amani Oruwariye, ARI | 11 |
| 2. Justin Simmons, SEA | 10 | |
| 3. Trevon Diggs, DAL | 10 | |
| 4. Jessie Bates III, CIN | 8 | |
| 5. Fred Warner, SF | 8 | |