League Leaders - Offense
| Passing Yards | Complete List | |
Trevor Lawrence
|
1. Trevor Lawrence, JAX | 2103 |
| 2. Will Levis, TEN | 1749 | |
| 3. Alexander Sharpton, CLE | 1673 | |
| 4. Bryce Young, CAR | 1648 | |
| 5. Anthony Richardson, ANC | 1581 | |
| Rushing Yards | Complete List | |
D'Andre Swift
|
1. D'Andre Swift, PHI | 559 |
| 2. Travis Etienne Jr, SEA | 500 | |
| 3. Big Mack, CAR | 492 | |
| 4. Christian McCaffrey, LAR | 449 | |
| 5. Sean Saunders, WAS | 437 | |
| Receiving Yards | Complete List | |
Jamille Willis
|
1. Jamille Willis, JAX | 701 |
| 2. Christian Watson, ANC | 660 | |
| 3. Jaylen Waddle, CLE | 551 | |
| 4. Mike Evans, TEN | 533 | |
| 5. A.J. Brown, PHI | 521 | |
League Leaders - Defense
| Tackles | Complete List | |
Christian Harris
|
1. Christian Harris, HST | 38 |
| 2. Ivan Pace Jr, NO | 35 | |
| 3. Devin Bush, SEA | 31 | |
| 4. Roquan Smith, BAL | 31 | |
| 5. Nathan Justice, WAS | 30 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 10 |
| 2. Micah Parsons, NYJ | 8 | |
| 3. Nick Bosa, SF | 7 | |
| 4. Maxx Crosby, LV | 7 | |
| 5. Joey Bosa, CLE | 6 | |
| Interceptions | Complete List | |
Kelee Ringo
|
1. Kelee Ringo, JAX | 6 |
| 2. Jordan Whitehead, WAS | 6 | |
| 3. Jaquan Brisker, CHI | 5 | |
| 4. Derwin James Jr, HNL | 5 | |
| 5. Martin Emerson Jr, CLE | 4 | |