League Leaders - Offense
| Passing Yards | Complete List | |
Brock Purdy
|
1. Brock Purdy, CHO | 5990 |
| 2. Malik Willis, SAC | 5458 | |
| 3. Desmond Dillard, DEN | 5138 | |
| 4. Bryce Young, CAR | 4951 | |
| 5. Carson Beck, SF | 4906 | |
| Rushing Yards | Complete List | |
Josh Jacobs
|
1. Josh Jacobs, LV | 1776 |
| 2. Dylan Edwards, NO | 1663 | |
| 3. Isiah Pacheco, KC | 1655 | |
| 4. Najee Harris, PIT | 1561 | |
| 5. De'Von Achane, LON | 1435 | |
| Receiving Yards | Complete List | |
Emeka Egbuka Sr
|
1. Emeka Egbuka Sr, CAR | 2020 |
| 2. Anthony Schwartz, CHO | 1605 | |
| 3. Davante Adams, TB | 1565 | |
| 4. Garrett Wilson, BKN | 1556 | |
| 5. Terry McLaurin, SAC | 1472 | |
League Leaders - Defense
| Tackles | Complete List | |
Devin Lloyd
|
1. Devin Lloyd, JAX | 108 |
| 2. Harold Perkins, JAX | 102 | |
| 3. Danny Stutsman, IND | 97 | |
| 4. Marvin Jones Jr., PHI | 93 | |
| 5. Barrett Carter, CLE | 92 | |
| Sacks | Complete List | |
T.J. Watt
|
1. T.J. Watt, PIT | 18 |
| 2. Rashan Gary, GB | 17 | |
| 3. Josh Uche, DEN | 17 | |
| 4. Nick Bosa, SF | 16 | |
| 5. Lukas Van Ness, LAR | 15 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, DEN | 12 |
| 2. Jessie Bates III, ATL | 11 | |
| 3. Nate Hobbs, LV | 11 | |
| 4. Drew Sanders, DEN | 9 | |
| 5. Jaycee Horn, CAR | 9 | |