League Leaders - Offense
| Passing Yards | Complete List | |
Jameis Winston
|
1. Jameis Winston, GB | 2667 |
| 2. Aaron Rodgers, MIA | 2595 | |
| 3. Kirk Cousins, MIN | 2563 | |
| 4. Malik Willis, BUF | 2479 | |
| 5. Trevor Lawrence, ATL | 2436 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, NE | 894 |
| 2. Raheem Mostert, GB | 879 | |
| 3. Christian McCaffrey, NO | 824 | |
| 4. Javonte Williams, PIT | 737 | |
| 5. Nick Chubb, LV | 656 | |
| Receiving Yards | Complete List | |
George Pickens
|
1. George Pickens, GB | 1071 |
| 2. Tyler Boyd, MIN | 1066 | |
| 3. Robert Tonyan, NE | 1006 | |
| 4. Travis Kelce, MIA | 975 | |
| 5. DeVonta Smith, LAR | 800 | |
League Leaders - Defense
| Tackles | Complete List | |
Eric Kendricks
|
1. Eric Kendricks, CIN | 58 |
| 2. Bobby Okereke, SEA | 54 | |
| 3. Jordyn Brooks, IND | 44 | |
| 4. Jerome Baker, JAX | 43 | |
| 5. Jordan Hicks, LAC | 42 | |
| Sacks | Complete List | |
Alex Highsmith
|
1. Alex Highsmith, ATL | 11 |
| 2. DeMarcus Lawrence, LV | 10 | |
| 3. Nick Bosa, CIN | 8 | |
| 4. T.J. Watt, MIN | 8 | |
| 5. Micah Parsons, ARI | 7 | |
| Interceptions | Complete List | |
Trevon Diggs
|
1. Trevon Diggs, GB | 9 |
| 2. Kyle Hamilton, GB | 6 | |
| 3. Sauce Gardner, CHI | 6 | |
| 4. Tariq Woolen, BUF | 5 | |
| 5. Tre'von Moehrig, CHI | 4 | |