League Leaders - Offense
| Passing Yards | Complete List | |
Johnny Kincaid
|
1. Johnny Kincaid, PIT | 5574 |
| 2. Russell Wilson, DEN | 3864 | |
| 3. Aaron Rodgers, GB | 3809 | |
| 4. Ronnie Darby, TEN | 3785 | |
| 5. Derek Carr, LV | 3490 | |
| Rushing Yards | Complete List | |
Najee Harris
|
1. Najee Harris, PIT | 1456 |
| 2. Derrick Henry, TEN | 1264 | |
| 3. Jonathan Taylor, IND | 1178 | |
| 4. Aaron Jones, GB | 1121 | |
| 5. Nick Chubb, CLE | 1091 | |
| Receiving Yards | Complete List | |
George Pickens
|
1. George Pickens, PIT | 1674 |
| 2. Terry McLaurin, WAS | 1368 | |
| 3. Michael Thomas, NO | 1306 | |
| 4. Cooper Kupp, LAR | 1300 | |
| 5. Mecole Hardman, PIT | 1289 | |
League Leaders - Defense
| Tackles | Complete List | |
Lavonte David
|
1. Lavonte David, TB | 86 |
| 2. Devin White, TB | 78 | |
| 3. Jeremiah Owusu-Koramoah, CLE | 76 | |
| 4. Logan Wilson, CIN | 73 | |
| 5. Divine Deablo, LV | 71 | |
| Sacks | Complete List | |
Chase Young
|
1. Chase Young, WAS | 18 |
| 2. T.J. Watt, PIT | 18 | |
| 3. Myles Garrett, CLE | 17 | |
| 4. Alex Highsmith, PIT | 14 | |
| 5. Haason Reddick, PHI | 14 | |
| Interceptions | Complete List | |
Jaycee Horn
|
1. Jaycee Horn, CAR | 7 |
| 2. Rasul Douglas, GB | 6 | |
| 3. Lonnie Riles, PHI | 6 | |
| 4. Kamren Curl, WAS | 6 | |
| 5. Taylor Rapp, LAR | 6 | |