League Leaders - Offense
| Passing Yards | Complete List | |
Will Beamen
|
1. Will Beamen, TB | 3662 |
| 2. Kyler Murray, ARI | 3323 | |
| 3. Aaron Rodgers, GB | 3010 | |
| 4. Cary Pryce, LAR | 3009 | |
| 5. Joe Burrow, CIN | 2915 | |
| Rushing Yards | Complete List | |
Baba Yaga
|
1. Baba Yaga, MIA | 1166 |
| 2. James Cook, BUF | 1109 | |
| 3. Najee Harris, NE | 1091 | |
| 4. Larry Williams, CAR | 965 | |
| 5. Jonathan Taylor, LV | 954 | |
| Receiving Yards | Complete List | |
Dion Kilgore
|
1. Dion Kilgore, CIN | 1824 |
| 2. Christian Watson, GB | 1495 | |
| 3. Cooper Kupp, LAR | 1204 | |
| 4. Jameson Williams, DET | 1144 | |
| 5. Justin Ware, PIT | 1109 | |
League Leaders - Defense
| Tackles | Complete List | |
Troy Andersen
|
1. Troy Andersen, ATL | 70 |
| 2. Micah McFadden, NYG | 63 | |
| 3. Pete Werner, NO | 60 | |
| 4. Darnay Holmes, NYG | 53 | |
| 5. Jerome Baker, TEN | 53 | |
| Sacks | Complete List | |
Chase Young
|
1. Chase Young, WAS | 15 |
| 2. Micah Parsons, DAL | 12 | |
| 3. Myles Garrett, CLE | 8 | |
| 4. Denzel Sherman, NO | 8 | |
| 5. Jadeveon Clowney, ARI | 8 | |
| Interceptions | Complete List | |
Ifeatu Melifonwu
|
1. Ifeatu Melifonwu, MIA | 11 |
| 2. Marlon Humphrey, HOU | 10 | |
| 3. Malachi Bates, CAR | 10 | |
| 4. Derwin James Jr, LAC | 8 | |
| 5. Julian Blackmon, IND | 8 | |