League Leaders - Offense
| Passing Yards | Complete List | |
Mike Vick
|
1. Mike Vick, DEN | 5435 |
| 2. Cam Newton, ARI | 4003 | |
| 3. John Elway, LAC | 268 | |
| 4. Joe Montana, DAL | 103 | |
| 5. Brett Farve, ARI | 2 | |
| Rushing Yards | Complete List | |
Roger Craig
|
1. Roger Craig, NE | 855 |
| 2. Marshawn Lynch, JAX | 826 | |
| 3. Reggie Bush, GB | 737 | |
| 4. Earl Campbell, LAC | 598 | |
| 5. Cam Newton, ARI | 389 | |
| Receiving Yards | Complete List | |
Isaac Bruce
|
1. Isaac Bruce, BKN | 1323 |
| 2. Calvin Johnson, BUF | 1124 | |
| 3. Randy Moss, DAL | 993 | |
| 4. Larry Fitzgerald Jr, ARI | 932 | |
| 5. Devin Hester, CAR | 819 | |
League Leaders - Defense
| Tackles | Complete List | |
Brian ########
|
1. Brian ########, NYJ | 62 |
| 2. Darren Woodson, ATL | 48 | |
| 3. Charles Tillman, NO | 47 | |
| 4. Rod Woodson, NYJ | 43 | |
| 5. Kam Chancellor, CAR | 41 | |
| Sacks | Complete List | |
DeMarcus Ware
|
1. DeMarcus Ware, ARI | 11 |
| 2. Alan Page, IND | 7 | |
| 3. Dwight Freeney, BUF | 7 | |
| 4. "Mean" Joe Greene, LAC | 6 | |
| 5. Howie Long, SEA | 6 | |
| Interceptions | Complete List | |
Kam Chancellor
|
1. Kam Chancellor, CAR | 6 |
| 2. John Lynch, IND | 3 | |
| 3. Brian ########, NYJ | 3 | |
| 4. Richard Sherman, DET | 3 | |
| 5. Mel Blount, GB | 3 | |