League Leaders - Offense
| Passing Yards | Complete List | |
Desmond Ridder
|
1. Desmond Ridder, NYG | 5050 |
| 2. Malik Willis, NO | 3790 | |
| 3. Kenny Pickett, WAS | 3270 | |
| 4. Brock Purdy, TB | 1638 | |
| 5. James Cook, NE | 4 | |
| Rushing Yards | Complete List | |
James Cook
|
1. James Cook, NE | 2464 |
| 2. Breece Hall, SEA | 1813 | |
| 3. Isiah Pacheco, NYG | 1187 | |
| 4. Dameon Pierce, PHI | 1094 | |
| 5. Brian Robinson Jr, TEN | 1045 | |
| Receiving Yards | Complete List | |
Jameson Williams
|
1. Jameson Williams, LV | 2146 |
| 2. Christian Watson, BAL | 1944 | |
| 3. Tyquan Thornton, CAR | 1315 | |
| 4. Velus Jones Jr, SF | 979 | |
| 5. Trey McBride, HOU | 960 | |
League Leaders - Defense
| Tackles | Complete List | |
Quay Walker
|
1. Quay Walker, TEN | 83 |
| 2. Trent McDuffie, PIT | 59 | |
| 3. Tariq Woolen, TEN | 55 | |
| 4. Percy Butler, NO | 49 | |
| 5. Malcolm Rodriguez, WAS | 42 | |
| Sacks | Complete List | |
Christian Harris
|
1. Christian Harris, LV | 15 |
| 2. George Karlaftis, LAR | 13 | |
| 3. Malcolm Rodriguez, WAS | 13 | |
| 4. Aidan Hutchinson, BAL | 10 | |
| 5. Amare Barno, MIA | 7 | |
| Interceptions | Complete List | |
Nick Cross
|
1. Nick Cross, LAR | 9 |
| 2. Derek Stingley Jr, LV | 8 | |
| 3. Andrew Booth Jr, LAC | 8 | |
| 4. Josh Blackwell, IND | 7 | |
| 5. Kerby Joseph, LAR | 7 | |