League Leaders - Offense
| Passing Yards | Complete List | |
Lamar Jackson
|
1. Lamar Jackson, LAR | 6061 |
| 2. Zach Wilson, BAL | 5982 | |
| 3. Daniel Jones, GB | 5722 | |
| 4. Desmond Ridder, NYG | 5050 | |
| 5. Tom Brady, LAC | 4984 | |
| Rushing Yards | Complete List | |
James Cook
|
1. James Cook, NE | 2464 |
| 2. Kene Nwangwu, CAR | 2258 | |
| 3. Christian McCaffrey, KC | 2158 | |
| 4. Josh Jacobs, CHI | 2120 | |
| 5. Breece Hall, SEA | 1813 | |
| Receiving Yards | Complete List | |
D.J. Chark Jr
|
1. D.J. Chark Jr, SEA | 2184 |
| 2. Jameson Williams, LV | 2146 | |
| 3. Calvin Ridley, GB | 1973 | |
| 4. Christian Watson, BAL | 1944 | |
| 5. David Njoku, ARI | 1791 | |
League Leaders - Defense
| Tackles | Complete List | |
Quay Walker
|
1. Quay Walker, TEN | 83 |
| 2. Lavonte David, PHI | 69 | |
| 3. Trent McDuffie, PIT | 59 | |
| 4. Rasul Douglas, PIT | 59 | |
| 5. Jayron Kearse, CIN | 59 | |
| Sacks | Complete List | |
Matthew Judon
|
1. Matthew Judon, DET | 25 |
| 2. Aaron Donald, LAC | 21 | |
| 3. Von Miller, LAC | 19 | |
| 4. Micah Parsons, WAS | 18 | |
| 5. Haason Reddick, PIT | 16 | |
| Interceptions | Complete List | |
Justin Simmons
|
1. Justin Simmons, DAL | 17 |
| 2. Chris Wilcox, SEA | 16 | |
| 3. Trevon Diggs, DEN | 14 | |
| 4. Darnell Savage, DEN | 14 | |
| 5. Isaiah Simmons, NYG | 14 | |