League Leaders - Offense
| Passing Yards | Complete List | |
Donald Allen
|
1. Donald Allen, NE | 1732 |
| Rushing Yards | Complete List | |
Zach Lindsey
|
1. Zach Lindsey, CAR | 514 |
| 2. Kyle Perriman, NYJ | 95 | |
| 3. Michael Hayes, IND | 54 | |
| 4. Josh Felix, DUB | 41 | |
| 5. Jimmie Bradford, JAX | 10 | |
| Receiving Yards | Complete List | |
Terrell Owens
|
1. Terrell Owens, DAL | 1177 |
| 2. J.T. Walls, LON | 629 | |
| 3. Will Wright, SEA | 508 | |
| 4. Jay Hunt, LV | 466 | |
| 5. Jimmie Bradford, JAX | 403 | |
League Leaders - Defense
| Tackles | Complete List | |
Denario Dalton
|
1. Denario Dalton, DUB | 14 |
| 2. Dom McCullers, LAR | 11 | |
| 3. Will Stark, LV | 11 | |
| 4. Troy Polamalu, NYG | 10 | |
| 5. Marco Burnett, LAR | 10 | |
| Sacks | Complete List | |
Melvin Ware
|
1. Melvin Ware, SEA | 7 |
| 2. Blake Picard, NO | 3 | |
| 3. Amar'e Rush, DUB | 3 | |
| 4. Aiden Brenner, KC | 2 | |
| 5. Bernard Beatty, JAX | 1 | |
| Interceptions | Complete List | |
Dom McCullers
|
1. Dom McCullers, LAR | 2 |
| 2. Damion McDougal, PIT | 2 | |
| 3. Kaleb Bond, CLE | 2 | |
| 4. Aiden Brenner, KC | 1 | |
| 5. Troy Polamalu, NYG | 1 | |