League Leaders - Offense
| Passing Yards | Complete List | |
Matthew Stafford
|
1. Matthew Stafford, DUB | 3274 |
| 2. Anthony Richardson, LAR | 2345 | |
| 3. Jimmy Garoppolo, DAL | 2177 | |
| 4. Malik Willis, TEN | 2029 | |
| 5. Kenny Pickett, LV | 2000 | |
| Rushing Yards | Complete List | |
Zach Lindsey
|
1. Zach Lindsey, CAR | 514 |
| 2. Christian McCaffrey, MIN | 462 | |
| 3. Austin Ekeler, NO | 444 | |
| 4. Bijan Robinson, HOU | 443 | |
| 5. Dalvin Cook, DUB | 434 | |
| Receiving Yards | Complete List | |
Ja'Marr Chase
|
1. Ja'Marr Chase, DUB | 1201 |
| 2. Jameson Williams, DUB | 1193 | |
| 3. Terrell Owens, DAL | 1177 | |
| 4. Jordan Addison, GB | 747 | |
| 5. Devin Duvernay, BAL | 662 | |
League Leaders - Defense
| Tackles | Complete List | |
Eric Kendricks
|
1. Eric Kendricks, DUB | 30 |
| 2. Divine Deablo, BAL | 24 | |
| 3. Kelee Ringo, DUB | 23 | |
| 4. Rasul Douglas, CAR | 22 | |
| 5. Amani Hooker, DUB | 21 | |
| Sacks | Complete List | |
Baron Browning
|
1. Baron Browning, GB | 13 |
| 2. Chandler Jones, JAX | 10 | |
| 3. Khalil Mack, TB | 10 | |
| 4. Danielle Hunter, NYJ | 9 | |
| 5. Travon Walker, GB | 9 | |
| Interceptions | Complete List | |
Amani Hooker
|
1. Amani Hooker, DUB | 7 |
| 2. Jonathan Robertson, NO | 6 | |
| 3. Kristian Fulton, ARI | 6 | |
| 4. Deane Leonard, DUB | 6 | |
| 5. Denzel Ward, LON | 6 | |