League Leaders - Offense
| Passing Yards | Complete List | |
Johnny Manziel
|
1. Johnny Manziel, MIA | 6047 |
| 2. Anthony Richardson, IND | 5960 | |
| 3. Casey Amerson, DEN | 5193 | |
| 4. Justin Herbert, LAC | 5077 | |
| 5. Trevor Lawrence, JAX | 5055 | |
| Rushing Yards | Complete List | |
Julian Lacey
|
1. Julian Lacey, HOU | 1622 |
| 2. Trent Scott, LV | 1424 | |
| 3. Morgan Crawford, PHI | 1320 | |
| 4. Trey Benson, ARI | 1217 | |
| 5. Eric Towns, BAL | 1191 | |
| Receiving Yards | Complete List | |
Ray Snell
|
1. Ray Snell, DEN | 2516 |
| 2. Jordan Young, MIA | 2229 | |
| 3. Joey Raymond, NO | 1594 | |
| 4. Leo Eddins, NYJ | 1567 | |
| 5. Robert Jenkins, NE | 1550 | |
League Leaders - Defense
| Tackles | Complete List | |
Courtney Lewis
|
1. Courtney Lewis, NO | 91 |
| 2. Devin White, WAS | 89 | |
| 3. Nick Cross, KC | 83 | |
| 4. Junior Colson, LAC | 81 | |
| 5. Nick Bolton, KC | 77 | |
| Sacks | Complete List | |
Cedric Johnson
|
1. Cedric Johnson, LV | 18 |
| 2. Ron Benedict, LAR | 17 | |
| 3. Will Anderson Jr, HOU | 15 | |
| 4. Travon Walker, JAX | 15 | |
| 5. Cal Borden, CAR | 15 | |
| Interceptions | Complete List | |
Randy Langford
|
1. Randy Langford, MIA | 14 |
| 2. Calen Bullock, HOU | 11 | |
| 3. Will Faulkner, DEN | 11 | |
| 4. Cooper DeJean, MIA | 11 | |
| 5. Cole Bishop, BUF | 10 | |