| Player Passing Statistics | ||||||||||
| Team | Cmp | Att | Cmp% | Yds | AVG | Long | TD | Int | Sack | Rate |
| 1. Lyle McCollum, DET | 28 | 41 | 68.3 | 434 | 10.6 | 75 | 5 | 0 | 5 | 142.7 |
| 2. Dak Prescott, DAL | 29 | 38 | 76.3 | 379 | 10.0 | 61 | 2 | 2 | 0 | 101.8 |
| 3. Desmond Ridder, ATL | 25 | 33 | 75.8 | 367 | 11.1 | 44 | 3 | 3 | 3 | 103.7 |
| 4. Matt Cooper, NE | 21 | 21 | 100.0 | 268 | 12.8 | 27 | 4 | 0 | 1 | 158.3 |
| 5. Jonathan Monroe, SEA | 15 | 24 | 62.5 | 260 | 10.8 | 51 | 3 | 2 | 3 | 104.3 |
| 6. Trey Lance, SF | 14 | 30 | 46.7 | 247 | 8.2 | 54 | 4 | 3 | 1 | 75.3 |
| 7. Ben Delgado, WAS | 15 | 28 | 53.6 | 238 | 8.5 | 30 | 2 | 0 | 0 | 105.5 |
| 8. Malik Willis, NYJ | 15 | 19 | 78.9 | 158 | 8.3 | 17 | 1 | 2 | 3 | 78.4 |
| 9. Tyler Huntley, SEA | 0 | 1 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 0 | 39.6 |