League Leaders - Offense
| Passing Yards | Complete List | |
C.J. Stroud
|
1. C.J. Stroud, NE | 908 |
| 2. Patrick Mahomes, KC | 863 | |
| 3. Joe Burrow, CIN | 765 | |
| 4. Josh Allen, BUF | 666 | |
| 5. Bill James, MIA | 620 | |
| Rushing Yards | Complete List | |
Saquon Barkley
|
1. Saquon Barkley, NYG | 345 |
| 2. Josh Jacobs, DAL | 334 | |
| 3. De'Von Achane, MIA | 306 | |
| 4. Isiah Pacheco, KC | 304 | |
| 5. Rhamondre Stevenson, NE | 277 | |
| Receiving Yards | Complete List | |
Tyquan Thornton
|
1. Tyquan Thornton, NE | 318 |
| 2. Xavier Worthy, ARI | 270 | |
| 3. Chris Olave, NO | 249 | |
| 4. Stefon Diggs, BUF | 243 | |
| 5. Treylon Burks, TEN | 238 | |
League Leaders - Defense
| Tackles | Complete List | |
Tycen Anderson
|
1. Tycen Anderson, CHI | 14 |
| 2. Jarrick Bernard-Converse, MIA | 13 | |
| 3. Troy Andersen, MIA | 12 | |
| 4. Javelin Guidry, MIA | 12 | |
| 5. Talanoa Hufanga, SF | 12 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, LV | 5 |
| 2. Patrick Queen, BAL | 5 | |
| 3. Alex Highsmith, PIT | 4 | |
| 4. Christopher Presley, MIA | 4 | |
| 5. Maxx Crosby, LV | 3 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, DEN | 3 |
| 2. Alphonso Williams, SEA | 3 | |
| 3. Kader Kohou, MIA | 3 | |
| 4. Caden Sterns, ARI | 3 | |
| 5. Christian Gonzalez, NE | 3 | |