League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Mahomes
|
1. Patrick Mahomes, KC | 5548 |
| 2. Brett Woody, SEA | 4994 | |
| 3. Josh Allen, BUF | 4810 | |
| 4. Steve McNair, TEN | 4789 | |
| 5. Michael Penix Jr, ATL | 4772 | |
| Rushing Yards | Complete List | |
Manny Kramer
|
1. Manny Kramer, ARI | 1773 |
| 2. Brian Truman, DET | 1447 | |
| 3. Isiah Pacheco, KC | 1369 | |
| 4. Damien Bailey, NE | 1268 | |
| 5. Harvey Muldrow, MIN | 1192 | |
| Receiving Yards | Complete List | |
Xavier Worthy
|
1. Xavier Worthy, KC | 1940 |
| 2. Darren James, ATL | 1932 | |
| 3. Randy Moss, NE | 1629 | |
| 4. Andre Reed, BUF | 1521 | |
| 5. Luke Kendrick, SEA | 1477 | |
League Leaders - Defense
| Tackles | Complete List | |
Junior Seau
|
1. Junior Seau, LAC | 111 |
| 2. Derrick Brooks, TB | 94 | |
| 3. Tremaine Edmunds, CHI | 92 | |
| 4. James McGhee, TB | 90 | |
| 5. Fred Warner, SF | 88 | |
| Sacks | Complete List | |
Chris Doleman
|
1. Chris Doleman, MIN | 19 |
| 2. Bruce Smith, BUF | 19 | |
| 3. Bernie Culliver, BAL | 19 | |
| 4. T.J. Watt, PIT | 18 | |
| 5. Jerry DuVall, ARI | 18 | |
| Interceptions | Complete List | |
Jaden Hicks
|
1. Jaden Hicks, KC | 16 |
| 2. Dax Hill, CIN | 15 | |
| 3. Calen Bullock, HOU | 12 | |
| 4. Night Train-Lane, DET | 9 | |
| 5. Chuck Massey, KC | 9 | |