League Leaders - Offense
| Passing Yards | Complete List | |
Jalen Hurts
|
1. Jalen Hurts, PIT | 6890 |
| 2. Patrick Mahomes, KC | 5842 | |
| 3. Desmond Ridder, CAR | 5710 | |
| 4. Tyler Bryant, DET | 5543 | |
| 5. Dak Prescott, DAL | 5471 | |
| Rushing Yards | Complete List | |
Derrick Henry
|
1. Derrick Henry, CLE | 1971 |
| 2. Antonio Gibson, WAS | 1779 | |
| 3. Jonathan Taylor, BUF | 1697 | |
| 4. Travis Etienne Jr, IND | 1579 | |
| 5. Kenneth Walker III, SEA | 1556 | |
| Receiving Yards | Complete List | |
Lord Megatron
|
1. Lord Megatron , CAR | 2230 |
| 2. Jayden Cooke, KC | 1941 | |
| 3. Calvin Austin III, PIT | 1870 | |
| 4. D.J. Moore, CAR | 1738 | |
| 5. Ja'Marr Chase, CIN | 1709 | |
League Leaders - Defense
| Tackles | Complete List | |
Patrick Queen
|
1. Patrick Queen, BAL | 110 |
| 2. Isaiah Simmons, ARI | 97 | |
| 3. Nakobe Dean, PHI | 96 | |
| 4. Tanner Muse, NYJ | 95 | |
| 5. Justin Ruiz, BAL | 88 | |
| Sacks | Complete List | |
Travon Walker
|
1. Travon Walker, DEN | 27 |
| 2. Chase Young, WAS | 24 | |
| 3. Josh Allen, TB | 23 | |
| 4. Alex Highsmith, PIT | 19 | |
| 5. Micah Parsons, DAL | 19 | |
| Interceptions | Complete List | |
Patrick Surtain II
|
1. Patrick Surtain II, DEN | 13 |
| 2. Nick Cross, IND | 11 | |
| 3. Valor Miller, DEN | 11 | |
| 4. Jayden Newsome, KC | 11 | |
| 5. L'Jarius Sneed, KC | 11 | |