League Leaders - Offense
| Passing Yards | Complete List | |
Dominique Stamper
|
1. Dominique Stamper, TB | 5039 |
| 2. Joe Burrow, CIN | 5015 | |
| 3. C.J. Stroud, HOU | 4967 | |
| 4. Brock Purdy, SF | 4961 | |
| 5. Gunner Rivers, SEA | 4926 | |
| Rushing Yards | Complete List | |
Isiah Pacheco
|
1. Isiah Pacheco, CIN | 1643 |
| 2. Priest Holmes II, MIN | 1254 | |
| 3. Bijan Robinson, ATL | 1174 | |
| 4. Jahmyr Gibbs, DET | 1167 | |
| 5. Eddie Glass, DAL | 1150 | |
| Receiving Yards | Complete List | |
Silas Foster
|
1. Silas Foster, DAL | 2125 |
| 2. Ja'Marr Chase, CIN | 1775 | |
| 3. RJ Hurts, SEA | 1721 | |
| 4. Xavier Worthy, KC | 1667 | |
| 5. Jameson Williams, DET | 1510 | |
League Leaders - Defense
| Tackles | Complete List | |
Junior Colson
|
1. Junior Colson, LAC | 107 |
| 2. Edgerrin Cooper, GB | 91 | |
| 3. Devin Bush, CLE | 90 | |
| 4. Patrick Queen, PIT | 89 | |
| 5. Tremaine Clements, JAX | 78 | |
| Sacks | Complete List | |
Beaux Jackson
|
1. Beaux Jackson, SEA | 17 |
| 2. Mason Graham, GB | 16 | |
| 3. Will Anderson Jr, HOU | 16 | |
| 4. Kevin Lowe, BAL | 16 | |
| 5. Joe Lawrence, CIN | 15 | |
| Interceptions | Complete List | |
Sergio Golston
|
1. Sergio Golston, NYG | 10 |
| 2. Sammy Thomas, SEA | 10 | |
| 3. Kyle Kitchens, SEA | 10 | |
| 4. Sheldon Gatewood, NYJ | 9 | |
| 5. Brian Gillispie, SEA | 9 | |