League Leaders - Offense
| Passing Yards | Complete List | |
Dak Prescott
|
1. Dak Prescott, DAL | 2069 |
| 2. Patrick Mahomes, KC | 1253 | |
| 3. Joe Burrow, CIN | 1039 | |
| 4. Aaron Rodgers, GB | 951 | |
| 5. Geno Smith, WAS | 929 | |
| Rushing Yards | Complete List | |
Melvin Gordon III
|
1. Melvin Gordon III, KC | 628 |
| 2. Tony Pollard, DAL | 389 | |
| 3. Travis Etienne Jr, JAX | 381 | |
| 4. Derrick Henry, TEN | 325 | |
| 5. Joe Mixon, CIN | 312 | |
| Receiving Yards | Complete List | |
CeeDee Lamb
|
1. CeeDee Lamb, DAL | 717 |
| 2. Jeremy Chamblin, NYJ | 644 | |
| 3. Dalton Schultz, DAL | 540 | |
| 4. Mecole Hardman, KC | 395 | |
| 5. Jalen Tolbert, DAL | 390 | |
League Leaders - Defense
| Tackles | Complete List | |
Anthony Brown
|
1. Anthony Brown, DAL | 20 |
| 2. Troy Ross, WAS | 19 | |
| 3. Cole Holcomb, WAS | 18 | |
| 4. Jamal Adams, SEA | 17 | |
| 5. Donovan Wilson, DAL | 16 | |
| Sacks | Complete List | |
Von Miller
|
1. Von Miller, BUF | 6 |
| 2. Myles Spence, GB | 6 | |
| 3. Zach Allen, SEA | 4 | |
| 4. Danielle Hunter, MIN | 4 | |
| 5. Montez Sweat, WAS | 3 | |
| Interceptions | Complete List | |
Trevon Diggs
|
1. Trevon Diggs, DAL | 5 |
| 2. Donovan Wilson, DAL | 4 | |
| 3. Jamal Adams, SEA | 4 | |
| 4. Adrian Phillips, MIA | 3 | |
| 5. Malik Hooker, DAL | 3 | |