League Leaders - Offense
| Passing Yards | Complete List | |
Clint Odom
|
1. Clint Odom, NYJ | 7226 |
| 2. Johnny Manziel, TB | 6796 | |
| 3. Sam Howell, MIA | 6159 | |
| 4. Jayden Daniels, WAS | 5653 | |
| 5. Caleb Williams, CHI | 5419 | |
| Rushing Yards | Complete List | |
Jonathon Brooks
|
1. Jonathon Brooks, CAR | 1772 |
| 2. Roderick Bibbs, LAC | 1443 | |
| 3. Kenneth Walker III, SEA | 1361 | |
| 4. Tiki Barber, NYG | 1308 | |
| 5. Juan Stapleton, CLE | 1232 | |
| Receiving Yards | Complete List | |
Ben Hoskins
|
1. Ben Hoskins, CAR | 2301 |
| 2. Garrett Wilson, NYJ | 2221 | |
| 3. Nick Quincy, NYJ | 1961 | |
| 4. Jaylen Waddle, MIA | 1958 | |
| 5. Zach Andrews, LAR | 1868 | |
League Leaders - Defense
| Tackles | Complete List | |
DeVante Kirkpatrick
|
1. DeVante Kirkpatrick, BUF | 87 |
| 2. Quay Walker, GB | 86 | |
| 3. Kas Cooper, LV | 82 | |
| 4. John Mitchell, IND | 81 | |
| 5. Payton Wilson, PIT | 77 | |
| Sacks | Complete List | |
Derrick Brooks
|
1. Derrick Brooks, NYG | 24 |
| 2. Kayvon Thibodeaux, NYG | 21 | |
| 3. Lawrence Taylor, NYG | 20 | |
| 4. Jalen Carter, PHI | 18 | |
| 5. Greg Rousseau, BUF | 16 | |
| Interceptions | Complete List | |
|
Darrell Harden
|
1. Darrell Harden, CAR | 16 |
| 2. Sauce Gardner, NYJ | 15 | |
| 3. Nate Wiggins, BAL | 12 | |
| 4. Tre Hawkins III, NYG | 11 | |
| 5. Daryl Hunter, CAR | 11 | |