League Leaders - Offense
| Passing Yards | Complete List | |
Patrick Fields
|
1. Patrick Fields, SF | 4459 |
| 2. Anthony Halin, SEA | 4182 | |
| 3. Glenn Snowden, DET | 4170 | |
| 4. Lamar Jackson, BAL | 4140 | |
| 5. Tyler Whiting, NE | 4051 | |
| Rushing Yards | Complete List | |
Ja McClellan
|
1. Ja McClellan, DAL | 1251 |
| 2. Isiah Pacheco, KC | 1000 | |
| 3. Jonathon Brooks, CAR | 974 | |
| 4. Dwight Pollard, HOU | 969 | |
| 5. Breece Hall, NYJ | 919 | |
| Receiving Yards | Complete List | |
Evan Stewart
|
1. Evan Stewart, CIN | 1641 |
| 2. Jameson Williams, DET | 1290 | |
| 3. Isaiah Bond, SEA | 1258 | |
| 4. Justin Jefferson, MIN | 1248 | |
| 5. Xavier Worthy, KC | 1163 | |
League Leaders - Defense
| Tackles | Complete List | |
Edgerrin Cooper
|
1. Edgerrin Cooper, GB | 81 |
| 2. Logan Wilson, TEN | 68 | |
| 3. Trevin Wallace, CAR | 63 | |
| 4. Darius Muasau, NYG | 61 | |
| 5. Junior Colson, LAC | 61 | |
| Sacks | Complete List | |
Micah Parsons
|
1. Micah Parsons, DAL | 17 |
| 2. Kemani Calloway, CAR | 13 | |
| 3. Leslie Moorehead, DAL | 11 | |
| 4. Will Anderson Jr, HOU | 11 | |
| 5. Rashan Gary, GB | 10 | |
| Interceptions | Complete List | |
Kelvin Culliver
|
1. Kelvin Culliver, HOU | 10 |
| 2. Joe Haden, MIA | 8 | |
| 3. Germaine Pratt, CIN | 8 | |
| 4. Talanoa Hufanga, SF | 8 | |
| 5. Richard Sherman, MIA | 8 | |