League Leaders - Offense
| Passing Yards | Complete List | |
Josh Allen
|
1. Josh Allen, BUF | 3487 |
| 2. C.J. Stroud, HOU | 3193 | |
| 3. Joe Burrow, CIN | 2992 | |
| 4. Brock Purdy, SF | 2982 | |
| 5. Patrick Mahomes, KC | 2834 | |
| Rushing Yards | Complete List | |
Jahmyr Gibbs
|
1. Jahmyr Gibbs, DET | 1142 |
| 2. Ezekiel Elliott, DAL | 1079 | |
| 3. Christian McCaffrey, SF | 1054 | |
| 4. Saquon Barkley, PHI | 950 | |
| 5. Tyrone Tracy Jr, NYG | 947 | |
| Receiving Yards | Complete List | |
Ja'Marr Chase
|
1. Ja'Marr Chase, CIN | 1454 |
| 2. D.K. Metcalf, SEA | 1074 | |
| 3. Deebo Samuel Sr, SF | 1035 | |
| 4. Xavier Worthy, KC | 999 | |
| 5. Keon Coleman, BUF | 879 | |
League Leaders - Defense
| Tackles | Complete List | |
Tremaine Edmunds
|
1. Tremaine Edmunds, CHI | 60 |
| 2. Patrick Queen, PIT | 58 | |
| 3. Zaire Franklin, IND | 55 | |
| 4. Demario Davis, NO | 54 | |
| 5. Edgerrin Cooper, GB | 53 | |
| Sacks | Complete List | |
Nick Bosa
|
1. Nick Bosa, SF | 20 |
| 2. Ed Oliver, BUF | 16 | |
| 3. Chop Robinson, MIA | 11 | |
| 4. Odafe Oweh, BAL | 11 | |
| 5. Brian Burns, NYG | 10 | |
| Interceptions | Complete List | |
Fred Warner
|
1. Fred Warner, SF | 7 |
| 2. Deonte Banks, NYG | 7 | |
| 3. Justin Simmons, ATL | 6 | |
| 4. Marshon Lattimore, NO | 6 | |
| 5. Bobby Okereke, NYG | 5 | |
